AFC Summer 1997
Held at the Sanger Centre, Cambridge
July 17th-18th 1997
Scientific Programme
Session 1
The involvement of the Wellcome Trust in bacterial genome sequencing
John Stephenson. Wellcome Trust
Sequencing of the Mycobacterium tuberculosis genome
Bart Barrell. Sanger Centre
Analysis of mycobacterial genomes
Stewart Cole. Institut Pasteur, Paris
Use of whole genome sequence of Haemophilus influenzae to investigate the biology of LPS
Richard Moxon. IMM, John Radcliffe Hospital, Oxford
Session 2
From genomics to targets and vaccines
Ken Duncan. Glaxo Wellcome, Stevenage
Comparative genome sequencing the pstS operon of Mycobacterium intracellulare, M.leprae and M.tuberculosis
Harry Thangaraj. RPMS, Hammersmith, London
A genome-wide search for genes involved in host susceptibility to human tuberculosis
R Bellamy et al. WellcomeTrust for Human Genomics, Oxford ; MRC, Gambia
Glycosyltransferases in mycobacteria: polyprenol-phosphomannose biosynthesis as an entry point
Paul R Wheeler. LSHTM, London
Use of yeast genome information
Johannes Hegemann. Justus-Liebig-Univ., Giessen, Germany
Session 3
Mycobacterial systematics: strengths and weaknesses of 16S rRNA sequencing
John Magee & Mike Goodfellow. PHLS, Newcastle upon Tyne
A porin-like gene of M. tuberculosis
R Senaratne et al. NIMR, London
Proteome analysis of microbial pathogens: applications and challenges
David O’Connor. Southampton University
Workshop 1: Bioinformatics
Lead Speaker: To be arranged
Antibiotic resistance: efflux genes in M. tuberculosis
Marian Blokpoel. Imperial College, London
Identification of MPT53, a novel secreted antigen of M. tuberculosis
Steve Michell. CVL, Weybridge
Finding families for orphan genes
Mark Pallen. Imperial College, London
Identification of potentially glycosylated mycobacterial lipoproteins
R Delahay. Imperial College, London
The WHO synthetic peptide initiative for new leprosy skin test reagents- the use of bioinformatics
To be arranged
Open discussion and short informal presentations
Workshop 2: Gene Function
Lead Speaker: Douglas Young. Imperial College, London
A novel approach to the trapping of activated promoters; promoter self-amplification
G Bachrach. NIMR, London
Upregulation of the M. tuberculosis haemoglobin-like hmp gene mRNA during entry into dormancy
A Coates. St Georges, London
Proteome maps from M. tuberculosis during infection
PD Butcher. St Georges, London
Open discussion and short informal presentations
Plenary session
Report back and discussion Panel
Jo Colston (chair), John Stephenson, Neil Stoker, Jeremy Dale, Douglas Young
Summary
Jo Colston