AFC Winter 2001 meeting

AFC Winter 2001

Held at The Royal Free Hospital, London

January 12th 2001

Scientific Programme

Session 1

The Molecular Epidemiology of TB in London 1995-1997
Tim McHugh, Royal Free Hospital, on behalf of the Principal Investigators of the London TB study Group

Effect of BCG vaccination on IFN? responses to mycobacterial antigens in UK schoolchildren as
compared to Malawian young adults : a potential correlate of vaccine–induced protective
immunity ?
R.E. Weir1, G. F. Black1,2, P.E.M. Fine1 and H.M. Dockrell1. 1Dept of Infectious and Tropical Diseases, LSH&TM, Keppel Street, London WC1E 7HT, 2Karonga Prevention Study, PO Box 46, Chilumba, Malawi

Effect of oxygen availability on the physiology and pathogenicity of Mycobacterium tuberculosis
Brian James and Philip Marsh, CAMR, Salisbury

Environmental survival of mycobacteria
Stephanie Taylor, Frans de Leij, Jeremy Dale, Molecular Microbiology Group, School of Biological Sciences, University of Surrey

The search for environmental mycobacteria in Karonga district, northern Malawi
Ben Chilima, Paul Fine and Penny Hirsch. London School of Hygiene & Tropical Medicine; IACR-
Rothamsted

The effect of stimulation of antigen presentation on M. tuberculosis infection
Stephen Jolles, Gerry Klaus, Ricardo Tascon and Jo Colston, The National Institute for Medical Research, London

Session 2

Deciphering the code of a mycobacterial enigma: understanding physiology from the
Mycobacterium leprae genome
P. Wheeler1 and ST Cole2. 1TB Research Group, VLA Weybridge, 2Institut Pasteur, France

ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X7-dependent process
inducing bacterial death by phagosome-lysosome fusion
Ian P. Fairbairn, David A. Lammas, Carmel B. Stober, Dinakantha S. Kumararatne. MRC Centre for Immune Regulation, Birmingham Medical School, Birmingham University

Genomic mutations and IS6110 in M. tuberculosis: Man as a model system?
Hasan Yesilkya, Jeremy Dale, Ken Forbes Medical Microbiology, Aberdeen University and Molecular
Microbiology Group, School of Biological Sciences, University of Surrey

Mycobacteria and the control of blood flow
Gerard Stansby, Christoph Berwanger, Yiu Che Chan and John Stanford. Department of Vascular Surgery, University of Newcastle upon Tyne and the Department of Medical Microbiology, RFUCMS, London

Widespread Occurrence of Mycobacterium tuberculosis-DNA from 18th-19th Century Hungarians
Helen Fletcher1, Helen D. Donoghue1, John Holton1, Ildicó Pap2 and Mark Spigelman1, 1Department of Medical Microbiology, University College London, London W1P 6DB, UK; 2Anthropology Department, Hungarian Natural History Museum, Ludovika tér 2, Budapest, Hungary H-1083