AFC Summer 2002

July 2002

Scientific Programme

Session 1
Mycobacteria versus Burkholderia
Eshwar Mahenthiralingam. University of Cardiff

The ESAT-6/WXG100 superfamily–and a new mycobacterial secretion system?
Mark J. Pallen

Expression of Toll-like receptors in the lungs of patients with pulmonary tuberculosis
Pauline T. Lukey*, Gael Fenhalls#, Ginette R. Webb*, Liesel Stevens-Muller#, Juanita Bezuidenhout#, Gillian Amphlett* and Ken Duncan*, *GlaxoSmithKline, Stevenage, UK and #University of Stellenbosch, Cape Town, South Africa

Session 2
Heterologous prime-boost immunisation strategies using plasmid DNA and BCG vaccination against tuberculosis
Ferraz J. C. Jr., Colston M. J., Espitia C., Yang M., Coade S., Raynaud C., Lowrie D. B., and Tascon R. E

Characterisation of a Mycobacterium tuberculosis H37Rv transposon library reveals insertions in 351 open reading frames and mutants with altered virulence
Ruth A. McAdam*, Selwyn Quan*, Debbie A. Smith#, Stoyan Bardarov+, Joanna C. Betts*, Fiona C. Cook*, Elizabeth U. Hooker*, Alan Lewis*, Peter Woollard*,Martin J. Everett*, Pauline T. Lukey*, Gregory J. Bancroft#, William R. Jacobs Jr+, and Ken Duncan*; *GlaxoSmithKline, #London School Of Hygiene & Tropical Medicine and +Albert Einstein College of Medicine

From CTL to TRL to MRU: The history of the reference laboratory
Tony Jenkins

Session 3
Are the Rpf family of growth factors essential for bacterial multiplication?
G V Mukamolova, O A Turapov, D I Young, C L Finan, A S Kaprelyants, D B Kell & M Young

Hsp65 DNA Vaccination in a mouse aerosol challenge system
B Walker, A Thiobhani, M Addawe, NIBSC

Phospho-threonine-binding FHA domains in mycobacterial proteins–neglected players in the phospho-signalling game?
Mark J. Pallen, Arshad M. Khan, Roy Chaudhuri

Session 4
Modification of nat, the gene encoding arylamine N-acetyltransferase which acetylates isoniazid, affects the growth and cellular morphology of mycobacteria
Sanjib Bhakta, Anna Upton, Frederique Pompeo, Mark Payton, Edith Sim, Tanya Parish

Operomics – towards an operon map of M. tuberculosis
Neil Stoker

Rapid Genomic and Biological Characterisation Of The Leicester School Tuberculosis Outbreak Strain
Jamila Shafi. Department of Microbiology and Immunology, University of Leicester, UK