AFC Summer 2006 meeting

AFC Summer 2006

Held at CEPR, Health Protection Agency, Porton Down

July 13th-14th 2006

Scientific Programme

Session 1: CEPR TB Programme
Overview of TB Research at CEPR
Philip Marsh

Guinea pig aerosol infection models in TB research
Ann Rawkins

Analysis of physiology and gene expression of M. tuberculosis grown in continuous culture
Joanna Bacon

From genes to vaccines: candidate selection and evaluation
Julia Vipond

Establishment of a non-human primate model of tuberculosis
Sally Sharpe

Session 2: Guest speakers

Transcriptomic analysis of host-pathogen interactions
Philip Butcher, Simon Waddell. St George’s University of London

Diagnostic and therapeutic potentials of antibodies for the control of tuberculosis
Juraj Ivanyi, Kings College London

Investigation of mechanisms of protection of recombinant viral vectors containing antigen 85A in a murine model
Clare Sander, University of Oxford

Session 3: Offered papers

The role of GlnE in Mycobacterium tuberculosis
Paul Carroll and Tanya Parish, Barts and the London, QM

Arylamine N-acetyltransferase, in mycobacteria, is a novel target for anti-TB therapy
Sanjib Bhakta, Isaac M. Westwood, Matthew C. Anderton, Angela Russell, Hilary Long, Gurdyal Singh Besra, Ajit Lalvani, Tanya Parish, Steve Davies, Edith Sim. Department of Pharmacology, University of Oxford.

Reassessment of optimal tuberculin skin test cut-off points for diagnosis of M. tuberculosis infection
Davinder Dosanjh, Mustafa Bakir, Jon Deeks, Ahmet Soysal, Kerry Millington, Yasemin Aslan, Serpil Efe, Imogen Staveley, Katie Ewer, Ajit Lalvani. Tuberculosis Immunology Group, University of Oxford

Lipid body-positive populations of tubercle bacilli in sputum – persisters responsible for protracted therapy?
Anna L Sherratt, Natalie J Garton, Rebecca J Smith, Robert C Free, Claire Senner, Jason Hinds, Kumar Rajakumar, Richard A Adegbola, Gurdyal S Besra, Philip D Butcher and Michael R Barer. University of Leicester

A transcriptomic approach for studying the activation of dendritic cells in response to mycobacterial infection
N Krishnan, J Brennan, M Yang, R Butler, R S Buxton, M Romano and R E Tascon. Division of Mycobacterial Research, MRC NIMR

Session 4: Offered papers

Mycobacterium tuberculosis chaperonin 60.1 influences the formation of granulomas in vivo.
Yanmin Hu, B Henderson, P Tormay, H Liu, P Lund, A Coates. Medical Microbiology, St George’s, University of London.

Structure and function of arylamine N-acetyltransferase of Mycobacterium marinum
Elizabeth Fullam, Sanjib Bhakta, Matthew Anderton, Angela Russell, Steve Davies, Martin Noble, Edith Sim. Department of Pharmacology, University of Oxford

Dynamic relationship between IFN-γ and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load during and after treatment of active tuberculosis
K.A. Millington, T.S.C. Hinks, J.A. Innes, S. Hackforth, J.J. Deeks, P. Klenerman and A. Lalvani. Tuberculosis Immunology Group, University of Oxford

Comparison of fluoroquinolone activites in a Durban study of serial sputum cfu counts
Rustomjee R, Fourie B, Davies G, Levin J and Mitchison DA. Medical Microbiology, St George’s, University of London.