AFC Summer 2006
Held at CEPR, Health Protection Agency, Porton Down
July 13th-14th 2006
Session 1: CEPR TB Programme
Overview of TB Research at CEPR
Guinea pig aerosol infection models in TB research
Analysis of physiology and gene expression of M. tuberculosis grown in continuous culture
From genes to vaccines: candidate selection and evaluation
Establishment of a non-human primate model of tuberculosis
Session 2: Guest speakers
Transcriptomic analysis of host-pathogen interactions
Philip Butcher, Simon Waddell. St George’s University of London
Diagnostic and therapeutic potentials of antibodies for the control of tuberculosis
Juraj Ivanyi, Kings College London
Investigation of mechanisms of protection of recombinant viral vectors containing antigen 85A in a murine model
Clare Sander, University of Oxford
Session 3: Offered papers
The role of GlnE in Mycobacterium tuberculosis
Paul Carroll and Tanya Parish, Barts and the London, QM
Arylamine N-acetyltransferase, in mycobacteria, is a novel target for anti-TB therapy
Sanjib Bhakta, Isaac M. Westwood, Matthew C. Anderton, Angela Russell, Hilary Long, Gurdyal Singh Besra, Ajit Lalvani, Tanya Parish, Steve Davies, Edith Sim. Department of Pharmacology, University of Oxford.
Reassessment of optimal tuberculin skin test cut-off points for diagnosis of M. tuberculosis infection
Davinder Dosanjh, Mustafa Bakir, Jon Deeks, Ahmet Soysal, Kerry Millington, Yasemin Aslan, Serpil Efe, Imogen Staveley, Katie Ewer, Ajit Lalvani. Tuberculosis Immunology Group, University of Oxford
Lipid body-positive populations of tubercle bacilli in sputum – persisters responsible for protracted therapy?
Anna L Sherratt, Natalie J Garton, Rebecca J Smith, Robert C Free, Claire Senner, Jason Hinds, Kumar Rajakumar, Richard A Adegbola, Gurdyal S Besra, Philip D Butcher and Michael R Barer. University of Leicester
A transcriptomic approach for studying the activation of dendritic cells in response to mycobacterial infection
N Krishnan, J Brennan, M Yang, R Butler, R S Buxton, M Romano and R E Tascon. Division of Mycobacterial Research, MRC NIMR
Session 4: Offered papers
Mycobacterium tuberculosis chaperonin 60.1 influences the formation of granulomas in vivo.
Yanmin Hu, B Henderson, P Tormay, H Liu, P Lund, A Coates. Medical Microbiology, St George’s, University of London.
Structure and function of arylamine N-acetyltransferase of Mycobacterium marinum
Elizabeth Fullam, Sanjib Bhakta, Matthew Anderton, Angela Russell, Steve Davies, Martin Noble, Edith Sim. Department of Pharmacology, University of Oxford
Dynamic relationship between IFN-γ and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load during and after treatment of active tuberculosis
K.A. Millington, T.S.C. Hinks, J.A. Innes, S. Hackforth, J.J. Deeks, P. Klenerman and A. Lalvani. Tuberculosis Immunology Group, University of Oxford
Comparison of fluoroquinolone activites in a Durban study of serial sputum cfu counts
Rustomjee R, Fourie B, Davies G, Levin J and Mitchison DA. Medical Microbiology, St George’s, University of London.