AFC Summer 2008 meeting

AFC Summer 2008

Held at the University of Leicester

July 10th-11th 2008

Scientific Programme

Session 1: Leicester-related symposium Part 1
Overview of TB research at Leicester
Mike Barer

Short read sequencing of Mycobacterium tuberculosis
NJ Loman, GM Weinstock, K Rajakumar, MR Barer & M Pallen.

Structural and Functional Characterisation of Complexes Formed by ESAT-6/CFP-10 Family Proteins
Kirsty Lightbody, Dariush Ilghari, Lorna Waters, Vaclav Veverka, Richard Williamson,Philip Renshaw and Mark Carr

The role of PknG in metabolic regulation in M. tuberculosis
Helen O’Hare, Rosario Durán, Jens Baumgartner, Marco Bellinzoni, Anne-Marie Wehenkel, Carlos Cervenansky, Pedro Alzari, Kai Johnsson

Session 2: Leicester-related symposium Part 2
Studies on lipid bodies of Mycobacterium tuberculosis: Survival of the fattest?
Su-Min Lee, Galina Mukamolova, Anna Sherratt, Natalie Garton and Mike Barer

TBIT: A Database for the integrated surveillance and management of tuberculosis cases, latent Tb infection (LTBI) and microbiology
Gerrit Woltmann, Rob Free, Joanne Malkin and Mike Barer.

Evaluation of mask sampling and rapid molecular assays in studying the transmission of tuberculosis in Leicester
Eddy Cheah, Joanne Malkin, Rob Free and Mike Barer

Session 3: Offered papers

The Mtb Cytochrome P450 Systems: structural insights and drug targeting
Kirsty J McLean, Colin Levy, David Leys and Andrew W Munro, University of Manchester

A simple mutation-based assay for determining the translational start sites of mycobacterial proteins
Katherine Smollett, Amanda Fivian-Hughes, Anchi Chang and Elaine Davis, MRC National Institute for Medical Research, London

Relationship of Th1 and FoxP3 positive T cells to the HIV-tuberculosis immune reconstitution inflammatory syndrome
Graeme A Meintjes, Katalin Wilkinson, Molebogeng Rangaka, Keira Skolimowska, Kerryn van Veen, Musaed Abrahams,Ronnett Seldon, Priscilla Mouton, Dominique J Pepper, Kevin Rebe, Gilles van Cutsem, Mark Patrick Nicol, Gary Maartens, Robert Wilkinson, University of Cape Town, South Africa

Characterization of a mycobacterial strain that fails to produce mature mycolic acids
Apoorva Bhatt, University of Birmingham

Novel Antimycobacterial Agents Targeting Mycolate Synthesis: Are They Pyrazinamide Like?
Amani Alnimr, Geoff Coxon, Tim McHugh, Stephen Gillespie. Royal Free and University College Medical School

Session 4: Offered papers

Oral BCG-Lipid protects from aerogenic M. bovis infection in the guinea pig
Simon Clark, Frank Aldwell, Martin Cross, Julia Vipond, Yper Hall, Allan Nadian, Ann Williams, Mark Chambers, HPA, CEPR, Porton

Identification of a crucial branching enzyme in mycobacterial arabinogalactan biosynthesis
Luke J. Alderwick, Helen L. Birch, Apoorva Bhatt, Doris Rittmann, Karin Krumbach, Albel Singh, Yu Bai, Todd L. Lowary, Lothar Eggeling, and Gurdyal S. Besra, University of Birmingham

MurE, an ATP dependent ligase in Mycobacterium tuberculosis: recombinant expression, purification and biochemical characterisation
Chandrakala Basavannacharya, Giles Robertson, Alexis Rubio, Edith Sim, Nicholas Keepand Sanjib Bhakta, Birkbeck, University of London

Genetic requirements for growth rate modulation during continuous culture in a chemostat
Dany JV Beste, Bhushan Bonde, Graham Stewart, Claudio Avignone-Rossa, Mike Bushell, Andrzej Kierzek and Johnjoe McFadden, University of Surrey, Guildford