AFC Winter 2006

Held at The Royal Free Hospital, London

January 20th 2006

Scientific Programme

Session 1
Markers of Treatment Response in Pulmonary Tuberculosis
Felicity Perrin, Yasmin Parsons, Clare Ling, Tim McHugh, Marc Lipman & Stephen Gillespie. Centre for Medical Microbiology, UCL, London

Macrophages undergo caspase-independent cell death after infection with M. tuberculosis
M.P. O’Sullivan, S. O’Leary , D. Kelly, A. ten Bokum & J. Keane. Institute of Molecular Medicine, Trinity College & St James Hospital, Dublin

Proteomic comparison of Mycobacterium avium subspecies paratuberculosis grown in vitro and isolated from clinical cases of ovine paratuberculosis
V.M. Hughes, S, Smith, A. Garcia-Sanchez & K Stevenson. Moredun Research Institute, Edinburgh

Transmission of M. tuberculosis undetected by PPD skin testing
S.T.B. Anderson,S.M. Newton, J.R. Brown, A. Williams, R.N. Davidson, M. Nicol, M.Levin, R.J.Wilkinson & K.A.Wilkinson. Department of Paediatrics, Imperial College, London.

A new tool for studying the immune response of the guinea pig model of tuberculosis
Julia Tree, Michael Elmore, Ann Williams & Philip Marsh. Centre for Emergency Response and Preparedness, Health Protection Agency, Salisbury

Boosting of T cell responses in either BCG vaccinated or latently infected with mycobacterium tuberculosis subjects using MVA expressing 85A – results of phase I trials
A.A. Pathan, C.R. Sander, N. Beveridge, H.A. Fletcher, F. Gleeson, R.J.O. Davies, G. Pasvol, A.V.S. Hill & H. McShane. Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford

Session 2

Immune responses induced by infant BCG vaccination in Malawi and the UK
M.K. Lalor, A.Ben-Smith, R.E.Weir, P.Gorak-Stolinska, S. Floyd, K.Makamo, R. Blitz, H.Mvula, M.J.Newport, K. Branson, A. Jahn, A.C.Crampin, P.E.Fine & H.M.Dockrell. London School of Hygiene & Tropical Medicine, London

Isoprenoid biosynthesis in Mycobacterium tuberculosis- a potential new drug target?
Amanda Brown, Matthias Eberl,  Tanya Parish, Barts & the London, QMSMD, London

Sputum induction as a non-invasive method of detecting clinically elevant immune responses in all patients with tuberculosis
RAM Breen, GA Hardy, I Cropley, G Janossy & MCI Lipman. Depts Thoracic & HIV Medicine, Royal Free Hospital. London

Ecotypes of the M. tuberculosis complex
Noel H. Smith, Kristin Kremer, Jacqueline Inwald, James Dale, Jeffrey R. Driscoll, Stephen V. Gordon, Dick van Soolingen, R. Glyn Hewinson & John Maynard Smith. Veterinary Laboratories Agency, Addlestone, Surrey.