AFC Winter 2008 meeting

AFC Winter 2008

Held at Barts & The London

January 11th 2008

Scientific Programme

Session 1
Validating drug targets in Mycobacterium tuberculosis
David M. Roberts, Paul Carroll, Karen Adie, Tanya Parish. Infectious Disease Research Institute, Seattle, USA

Unique transcriptome profiles of M.tuberculosis in human sputum
Simon Waddell, Natalie Garton, Claire Senner, Jason Hinds, Mike Barer and Philip Butcher. St George’s University of London

Dissecting M.tuberculosis driven signalling pathways in human macrophages causing tissue destruction
L. Rand, J.A. Green, P.T.G. Elkington, J. S. Friedland. Infectious Diseases and Immunity, Imperial College London

Rapid differentiation of rifampicin-resistant strains of Mycobacterium tuberculosis
Kim Mallard, Ghada S. Sharaf Eldon and Ruth McNerney. London School of Hygiene and Tropical Medicine

Heterogeneity of HupB, an iron-regulated protein of mycobacteria
Veena C Yeruva, Paul R. Wheeler, Stephen Gordon and Manjula Sritharan. School of Life Sciences, University of Hyderabad, India

Session 2

Bystander macrophage apoptosis after Mycobacterium tuberculosis H37Ra infection
Joseph Keane, Annemieke M.C. ten Bokum, Seonadh M. O’Leary, Deirdre M. Kelly, Mary P. O’Sullivan. Trinity College Dublin and St. James’s Hospital, Dublin, Ireland

Analysis of a single nucleotide polymorphism in M. bovis BCG
Debbie M. Hunt, José W. Saldanha, John F. Brennan, Pearline Benjamin, Jeffrey A. Cole, Claire L. Spreadbury and Roger S. Buxton. MRC National Institute for Medical Research.

Hypervirulence through gene deletion in Mycobacterium tuberculosis
Annemieke ten Bokum, Farah Movahedzadeh, Rosangela Frita, Sharon Kendall, Debbie Smith, Greg Bancroft and Neil Stoker. London School of Hygiene & Tropical Medicine

Deletion of hmp gene alters lipid biosynthesis of M. tuberculosis and leads to attenuation of the organism in macrophage and murine infection models
Yanmin Hu1, Gurdyal S. Besra,2 Sudagar S. Gurcha,2 Manfred Rohde3  Mahavir Singh3 and Anthony Coates1. 1 St George’s University of London, 2 School of Biosciences, The University of Birmingham, 3 Helmholtz Centre for Infection Research, Braunschweig, Germany

Survival of Mycobacterium bovis in protozoa
Cornelia Mardare, Frans de Leij & Jeremy W Dale. University of Surrey, Guildford