AFC Summer 2011 meeting

AFC Summer 2011

Held at the University of Surrey

July 8th 2011

Scientific Programme

Session 1: Surrey University

Interrogating transcriptomic data with a genome-scale model of metabolism: what does M. tuberculosis eat in vivo?
Bhushan Bonde, Dany Beste, Emma Laing, Andrzej M. Kierzek, Johnjoe McFadden

Cell death fates in Mycobacteruim tuberculosis infected             macrophages are influenced by multiplicity of infection, virulence, and strain characteristics
Rachel E. Butler, Priscille Brodin, Jichan Jang, Mi-Seon Jang, Hilde Smith, Jelle Thole, Brigitte Gicquel, Olivier Neyrolles and Graham R Stewart

Session 2

Exploring the therapeutic potential of a novel human IgA antibody against tuberculosis
Rajko Reljic, Sucharitha Balu, Jenny Woof and Juraj Ivanyi. St George’s, University of London

Genome Scale Modelling of Mycobacterium bovis and Mycobacterium bovis Bacille Calmette-Guérin
Emma Lofthouse, Paul Wheeler, Andrzej Kierzek, Dany Beste, Tom Mendum and Johnjoe McFadden. Tuberculosis Research Group, Animal Health and Veterinary Laboratories Agency,Weybridge

An evaluation of the safety and immunogenicity of MVA85A delivered by aerosol to the lungs of macaques
A.D. White, K. Gooch, L. Sibley, M.J. Dennis, G. Betts, A. Reyes-Sandoval, A. Williams, P.D. Marsh, H. McShane, S.A. Sharpe. Health Protection Agency, Centre for Emergency Preparedness and Response, Porton Down, Salisbury

Broad cytokine/chemokine response in peripheral blood stimulated with heparin-binding haemagglutinin following BCG vaccination of UK infants
Steven G. Smith, Sophie Lecher, Rose Blitz, Camille Locht, Hazel M. Dockrell. Department of Immunology and Infection, London School of Hygiene & Tropical Medicine, London

The use of low temperature incubation to screen for whole cell activity of drugs against persisters
D.Coleman, D.A.Mitchison, S Waddell, St Georges, University of London

Session 3

Mycobacterium leprae upregulates human beta defensins in cutaneous leprosy Type 1 Reactions
Anna L. Cogen, Steven L. Walker, Chrissy Roberts, Sushmita Dhakal, Rachel A. Hawksworth, Kishori Mahat , Diana N.J. Lockwood. Faculty of Infectious Tropical Diseases, Department of Clinical Research, London School of Hygiene and Tropical Medicine, London

Mycobacterium tuberculosis lineage influences innate immune response and is associated with distinct cell envelope lipids
Nitya Krishnan, Wladimir Malaga, Maxine Caws, Douglas.B.Young, Brian D. Robertson, Christophe Guilhot, Guy.E.Thwaites. Centre for Molecular Microbiology and Infection, Imperial College, London

The C-Terminal Domain of the Ethambutol target Mt-EmbC is a Lectin-like Carbohydrate Binding Module
Luke J. Alderwick, Georgina S. Lloyd, Hemza Ghadbane, John W. May, Apoorva Bhatt, Lothar Eggeling, Klaus Fütterer, Gurdyal S. Besra. School of Biosciences, University of Birmingham

A distinct profile of cytokine production correlates with and predicts BCG induced protection in a Mycobacterium bovis murine challenge model
Daryan A. Kaveh, Elihu Aranday-Cortes and Philip J. Hogarth, TB Research Group, Animal Health and Veterinary Laboratories Agency, Weybridge, Surrey

Insights into immigrant screening for tuberculosis from evaluation of practice and a multi-centre cohort study of cost-effectiveness
Manish Pareek, John P. Watson, L Peter Ormerod, Onn Min Kon, Gerrit Woltmann, Peter J White, Ibrahim Abubakar, Geoffrey P Garnett, Ajit Lalvani, Tuberculosis Research Unit, National Heart and Lung Institute, Imperial College London, UK & Department of Infectious Disease Epidemiology, Imperial College London, UK