AFC Meetings

AFC Summer 2008 meeting

AFC Summer 2008

Held at the University of Leicester

July 10th-11th 2008

Scientific Programme

Session 1: Leicester-related symposium Part 1
Overview of TB research at Leicester
Mike Barer

Short read sequencing of Mycobacterium tuberculosis
NJ Loman, GM Weinstock, K Rajakumar, MR Barer & M Pallen.

Structural and Functional Characterisation of Complexes Formed by ESAT-6/CFP-10 Family Proteins
Kirsty Lightbody, Dariush Ilghari, Lorna Waters, Vaclav Veverka, Richard Williamson,Philip Renshaw and Mark Carr

The role of PknG in metabolic regulation in M. tuberculosis
Helen O’Hare, Rosario Durán, Jens Baumgartner, Marco Bellinzoni, Anne-Marie Wehenkel, Carlos Cervenansky, Pedro Alzari, Kai Johnsson

Session 2: Leicester-related symposium Part 2
Studies on lipid bodies of Mycobacterium tuberculosis: Survival of the fattest?
Su-Min Lee, Galina Mukamolova, Anna Sherratt, Natalie Garton and Mike Barer

TBIT: A Database for the integrated surveillance and management of tuberculosis cases, latent Tb infection (LTBI) and microbiology
Gerrit Woltmann, Rob Free, Joanne Malkin and Mike Barer.

Evaluation of mask sampling and rapid molecular assays in studying the transmission of tuberculosis in Leicester
Eddy Cheah, Joanne Malkin, Rob Free and Mike Barer

Session 3: Offered papers

The Mtb Cytochrome P450 Systems: structural insights and drug targeting
Kirsty J McLean, Colin Levy, David Leys and Andrew W Munro, University of Manchester

A simple mutation-based assay for determining the translational start sites of mycobacterial proteins
Katherine Smollett, Amanda Fivian-Hughes, Anchi Chang and Elaine Davis, MRC National Institute for Medical Research, London

Relationship of Th1 and FoxP3 positive T cells to the HIV-tuberculosis immune reconstitution inflammatory syndrome
Graeme A Meintjes, Katalin Wilkinson, Molebogeng Rangaka, Keira Skolimowska, Kerryn van Veen, Musaed Abrahams,Ronnett Seldon, Priscilla Mouton, Dominique J Pepper, Kevin Rebe, Gilles van Cutsem, Mark Patrick Nicol, Gary Maartens, Robert Wilkinson, University of Cape Town, South Africa

Characterization of a mycobacterial strain that fails to produce mature mycolic acids
Apoorva Bhatt, University of Birmingham

Novel Antimycobacterial Agents Targeting Mycolate Synthesis: Are They Pyrazinamide Like?
Amani Alnimr, Geoff Coxon, Tim McHugh, Stephen Gillespie. Royal Free and University College Medical School

Session 4: Offered papers

Oral BCG-Lipid protects from aerogenic M. bovis infection in the guinea pig
Simon Clark, Frank Aldwell, Martin Cross, Julia Vipond, Yper Hall, Allan Nadian, Ann Williams, Mark Chambers, HPA, CEPR, Porton

Identification of a crucial branching enzyme in mycobacterial arabinogalactan biosynthesis
Luke J. Alderwick, Helen L. Birch, Apoorva Bhatt, Doris Rittmann, Karin Krumbach, Albel Singh, Yu Bai, Todd L. Lowary, Lothar Eggeling, and Gurdyal S. Besra, University of Birmingham

MurE, an ATP dependent ligase in Mycobacterium tuberculosis: recombinant expression, purification and biochemical characterisation
Chandrakala Basavannacharya, Giles Robertson, Alexis Rubio, Edith Sim, Nicholas Keepand Sanjib Bhakta, Birkbeck, University of London

Genetic requirements for growth rate modulation during continuous culture in a chemostat
Dany JV Beste, Bhushan Bonde, Graham Stewart, Claudio Avignone-Rossa, Mike Bushell, Andrzej Kierzek and Johnjoe McFadden, University of Surrey, Guildford

AFC Winter 2008 meeting

AFC Winter 2008

Held at Barts & The London

January 11th 2008

Scientific Programme

Session 1
Validating drug targets in Mycobacterium tuberculosis
David M. Roberts, Paul Carroll, Karen Adie, Tanya Parish. Infectious Disease Research Institute, Seattle, USA

Unique transcriptome profiles of M.tuberculosis in human sputum
Simon Waddell, Natalie Garton, Claire Senner, Jason Hinds, Mike Barer and Philip Butcher. St George’s University of London

Dissecting M.tuberculosis driven signalling pathways in human macrophages causing tissue destruction
L. Rand, J.A. Green, P.T.G. Elkington, J. S. Friedland. Infectious Diseases and Immunity, Imperial College London

Rapid differentiation of rifampicin-resistant strains of Mycobacterium tuberculosis
Kim Mallard, Ghada S. Sharaf Eldon and Ruth McNerney. London School of Hygiene and Tropical Medicine

Heterogeneity of HupB, an iron-regulated protein of mycobacteria
Veena C Yeruva, Paul R. Wheeler, Stephen Gordon and Manjula Sritharan. School of Life Sciences, University of Hyderabad, India

Session 2

Bystander macrophage apoptosis after Mycobacterium tuberculosis H37Ra infection
Joseph Keane, Annemieke M.C. ten Bokum, Seonadh M. O’Leary, Deirdre M. Kelly, Mary P. O’Sullivan. Trinity College Dublin and St. James’s Hospital, Dublin, Ireland

Analysis of a single nucleotide polymorphism in M. bovis BCG
Debbie M. Hunt, José W. Saldanha, John F. Brennan, Pearline Benjamin, Jeffrey A. Cole, Claire L. Spreadbury and Roger S. Buxton. MRC National Institute for Medical Research.

Hypervirulence through gene deletion in Mycobacterium tuberculosis
Annemieke ten Bokum, Farah Movahedzadeh, Rosangela Frita, Sharon Kendall, Debbie Smith, Greg Bancroft and Neil Stoker. London School of Hygiene & Tropical Medicine

Deletion of hmp gene alters lipid biosynthesis of M. tuberculosis and leads to attenuation of the organism in macrophage and murine infection models
Yanmin Hu1, Gurdyal S. Besra,2 Sudagar S. Gurcha,2 Manfred Rohde3  Mahavir Singh3 and Anthony Coates1. 1 St George’s University of London, 2 School of Biosciences, The University of Birmingham, 3 Helmholtz Centre for Infection Research, Braunschweig, Germany

Survival of Mycobacterium bovis in protozoa
Cornelia Mardare, Frans de Leij & Jeremy W Dale. University of Surrey, Guildford

AFC Summer 2007 meeting

AFC Summer 2007

Held at Churchill campus, University of Oxford

July 6th 2007

Scientific Programme

Session 1
BCG-MVA85A vaccination in humans: polyfunctional nature of antigen 85A-specific CD4+ T cell populations
Beveridge NER, Price DA, Casazza JP, Pathan AA, Sander CR, Asher TE, Ambrozak DR, Precopio ML, Scheinberg P, Alder NC, Roederer M, Koup RK, Douek DC, Hill AVS, McShane H. Oxford University

Control of gene expression in Mycobacterium tuberculosis by the SenX3 RegX3 two component system
Jade James and Tanya Parish. Barts and the London

Protection imparted by anti-IL-4 antibody in a murine model of M. tuberculosis infection: a potential immunotherapeutic agent?
E Roy, J Brennan, DB Lowrie & S Jolles. Cardiff University

Studying the soj gene of Mycobacterium tuberculosis
Rosangela M. Frita, Farahnaz Movahedzadeh, Annemieke ten Bokum, Neil G. Stoker. The Royal Veterinary College

An ABC transporter required for sugar uptake and virulence in Mycobacterium tuberculosis
Rachael Whalan and Roger Buxton. National Institute for Medical Research

Session 2

Quantification of global transcription patterns in Mycobacterium tuberculosis
Sidders, B., Wernisch, L., Withers, M., Kendall, SL., Cox, RA., Frita, R., Ten Bokum, A. and Stoker, NG. The Royal Veterinary College

Mycolic-acid specific T cell responses as a marker of tuberculosis
Montamat-Sicotte D, Millington K, Willcox C, Besra G, Innes J, Hackfoth S, Lammas D, Willcox B, Lalvani, A. Imperial College London

Regulation of narK2 and Mb1767 genes in M. bovis and M. tuberculosis
Christian Palavecino and Tanya Parish. Barts and the London.

Exploring intracellular M. tuberculosis transcriptomes from human dendritic cell and macrophage infection models
SJ Waddell, M Withers, L Tailleux, N Stoker, O Neyrolles & PD Butcher. St George’s University of London

AFC Winter 2007 meeting

AFC Winter 2007

Held at St Mary’s campus, Imperial College, London

January 12th 2007

Scientific Programme

Pre-meeting session

Discussion on withdrawal of Hycolin
Led by Ann Rawkins

Session 1
Frequency of Mycobacterium tuberculosis antigen specific IFN-γ-secreting T cells correlates with presence of pathology in tuberculosis
Timothy S.C. Hinks, Davinder P.S. Dosanjh, John A. Innes, Geoffrey Pasvol, Sarah Hackforth, Hansa Varia, Xiao-Qing Liu, Kerry A. Millington, Rubamalar Gunatheesan, Valerie Guyot-Revol, JonathanJ. Deeks & Ajit Lalvani. Tuberculosis Immunology Group, Imperial College London

Plant Expression and Production Methodologies for Recombinant TB antigiens: Scientific and Strategic Considerations for Ensuring Affordable Product Access for Poorer Populations in Need
Julian Ma and Harry Thangaraj. Centre for Management of Intellectual Property in Health R&D, Oxford

A new perspective on mycobacterial cell wall biosynthesis and the identification of potential drug targets
Luke J. Alderwick, Mathias Seidel, Lothar Eggeling & Gurdyal S. Besra. School of Biosciences, The University of Birmingham

Isoniazid assisted protective immunity in bovine tuberculosis
Dean GS, Rhodes SG, Wheeler PR, Villareal-Ramos B, Vordermeier HM. TB Research Group, VLA Weybridge

A novel transcriptional regulator of PE/PPE genes of Mycobacterium tuberculosis contributes to disease immunopathology
Sunali D. Goonesekera, Barry R. Bloom, Douglas B. Young, Samantha L. Sampson. Centre for Molecular Microbiology and Infection, Imperial College London

Session 2

Philip D’Arcy Hart memorial
Philip Draper on Behalf of the Acid fast Club

Neutrophil-mediated innate immune resistance to mycobacteria
Adrian R. Martineau Sandra M. NewtonKatalin A. WilkinsonBeate Kampmann Bridget M. Hall Niga Nawroly, Geoffrey E. Packe Robert N. Davidson Christopher J. GriffithsRobert J. Wilkinson. Wellcome Trust Centre for Research in Clinical Tropical Medicine, Imperial College London

Arabinosyl transferases in Mycobacterium tuberculosis
Renan Goude & Tanya Parish. Centre for Infectious Disease, Barts and the London

Brewing up resistance!
Claire Jenkins, Joanna Bacon, Catherine Arnold, Alpana Bose, Jon Allnutt, Ellie Shaw, Tim McHugh & Stephen Gillespie. Royal Free & University College Medical School, London, NW3 2QG

AFC Summer 2006 meeting

AFC Summer 2006

Held at CEPR, Health Protection Agency, Porton Down

July 13th-14th 2006

Scientific Programme

Session 1: CEPR TB Programme
Overview of TB Research at CEPR
Philip Marsh

Guinea pig aerosol infection models in TB research
Ann Rawkins

Analysis of physiology and gene expression of M. tuberculosis grown in continuous culture
Joanna Bacon

From genes to vaccines: candidate selection and evaluation
Julia Vipond

Establishment of a non-human primate model of tuberculosis
Sally Sharpe

Session 2: Guest speakers

Transcriptomic analysis of host-pathogen interactions
Philip Butcher, Simon Waddell. St George’s University of London

Diagnostic and therapeutic potentials of antibodies for the control of tuberculosis
Juraj Ivanyi, Kings College London

Investigation of mechanisms of protection of recombinant viral vectors containing antigen 85A in a murine model
Clare Sander, University of Oxford

Session 3: Offered papers

The role of GlnE in Mycobacterium tuberculosis
Paul Carroll and Tanya Parish, Barts and the London, QM

Arylamine N-acetyltransferase, in mycobacteria, is a novel target for anti-TB therapy
Sanjib Bhakta, Isaac M. Westwood, Matthew C. Anderton, Angela Russell, Hilary Long, Gurdyal Singh Besra, Ajit Lalvani, Tanya Parish, Steve Davies, Edith Sim. Department of Pharmacology, University of Oxford.

Reassessment of optimal tuberculin skin test cut-off points for diagnosis of M. tuberculosis infection
Davinder Dosanjh, Mustafa Bakir, Jon Deeks, Ahmet Soysal, Kerry Millington, Yasemin Aslan, Serpil Efe, Imogen Staveley, Katie Ewer, Ajit Lalvani. Tuberculosis Immunology Group, University of Oxford

Lipid body-positive populations of tubercle bacilli in sputum – persisters responsible for protracted therapy?
Anna L Sherratt, Natalie J Garton, Rebecca J Smith, Robert C Free, Claire Senner, Jason Hinds, Kumar Rajakumar, Richard A Adegbola, Gurdyal S Besra, Philip D Butcher and Michael R Barer. University of Leicester

A transcriptomic approach for studying the activation of dendritic cells in response to mycobacterial infection
N Krishnan, J Brennan, M Yang, R Butler, R S Buxton, M Romano and R E Tascon. Division of Mycobacterial Research, MRC NIMR

Session 4: Offered papers

Mycobacterium tuberculosis chaperonin 60.1 influences the formation of granulomas in vivo.
Yanmin Hu, B Henderson, P Tormay, H Liu, P Lund, A Coates. Medical Microbiology, St George’s, University of London.

Structure and function of arylamine N-acetyltransferase of Mycobacterium marinum
Elizabeth Fullam, Sanjib Bhakta, Matthew Anderton, Angela Russell, Steve Davies, Martin Noble, Edith Sim. Department of Pharmacology, University of Oxford

Dynamic relationship between IFN-γ and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load during and after treatment of active tuberculosis
K.A. Millington, T.S.C. Hinks, J.A. Innes, S. Hackforth, J.J. Deeks, P. Klenerman and A. Lalvani. Tuberculosis Immunology Group, University of Oxford

Comparison of fluoroquinolone activites in a Durban study of serial sputum cfu counts
Rustomjee R, Fourie B, Davies G, Levin J and Mitchison DA. Medical Microbiology, St George’s, University of London.

AFC Winter 2006 meeting

AFC Winter 2006

Held at The Royal Free Hospital, London

January 20th 2006

Scientific Programme

Session 1
Markers of Treatment Response in Pulmonary Tuberculosis
Felicity Perrin, Yasmin Parsons, Clare Ling, Tim McHugh, Marc Lipman & Stephen Gillespie. Centre for Medical Microbiology, UCL, London

Macrophages undergo caspase-independent cell death after infection with M. tuberculosis
M.P. O’Sullivan, S. O’Leary , D. Kelly, A. ten Bokum & J. Keane. Institute of Molecular Medicine, Trinity College & St James Hospital, Dublin

Proteomic comparison of Mycobacterium avium subspecies paratuberculosis grown in vitro and isolated from clinical cases of ovine paratuberculosis
V.M. Hughes, S, Smith, A. Garcia-Sanchez & K Stevenson. Moredun Research Institute, Edinburgh

Transmission of M. tuberculosis undetected by PPD skin testing
S.T.B. Anderson,S.M. Newton, J.R. Brown, A. Williams, R.N. Davidson, M. Nicol, M.Levin, R.J.Wilkinson & K.A.Wilkinson. Department of Paediatrics, Imperial College, London.

A new tool for studying the immune response of the guinea pig model of tuberculosis
Julia Tree, Michael Elmore, Ann Williams & Philip Marsh. Centre for Emergency Response and Preparedness, Health Protection Agency, Salisbury

Boosting of T cell responses in either BCG vaccinated or latently infected with mycobacterium tuberculosis subjects using MVA expressing 85A – results of phase I trials
A.A. Pathan, C.R. Sander, N. Beveridge, H.A. Fletcher, F. Gleeson, R.J.O. Davies, G. Pasvol, A.V.S. Hill & H. McShane. Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford

Session 2

Immune responses induced by infant BCG vaccination in Malawi and the UK
M.K. Lalor, A.Ben-Smith, R.E.Weir, P.Gorak-Stolinska, S. Floyd, K.Makamo, R. Blitz, H.Mvula, M.J.Newport, K. Branson, A. Jahn, A.C.Crampin, P.E.Fine & H.M.Dockrell. London School of Hygiene & Tropical Medicine, London

Isoprenoid biosynthesis in Mycobacterium tuberculosis- a potential new drug target?
Amanda Brown, Matthias Eberl,  Tanya Parish, Barts & the London, QMSMD, London

Sputum induction as a non-invasive method of detecting clinically elevant immune responses in all patients with tuberculosis
RAM Breen, GA Hardy, I Cropley, G Janossy & MCI Lipman. Depts Thoracic & HIV Medicine, Royal Free Hospital. London

Ecotypes of the M. tuberculosis complex
Noel H. Smith, Kristin Kremer, Jacqueline Inwald, James Dale, Jeffrey R. Driscoll, Stephen V. Gordon, Dick van Soolingen, R. Glyn Hewinson & John Maynard Smith. Veterinary Laboratories Agency, Addlestone, Surrey.

AFC Summer 2014 meeting (60th anniversary)

AFC Summer 2014

60th Anniversary meeting, Berlin

July 10-11 2014

Scientific Programme

Session 1: Berlin + Aeras Special

TB Research in Berlin Spanning 130 Years
Stefan Kaufmann, Max Planck Institute for Infection Biology

Interferons, Inflammation and Lung Injury in TB
Anca Dorhoi, MPIIB

Molecular profiling for host biomarker discovery in health and disease
Jeroen Maertzdorf, MPIIB

Individuality in disease: patient-specific and cell-specific gene expression in TB
January Weiner, MPIIB

Session 2: Offered papers

Metabolic models of mycobacteria: systems insights into pathogenesis
Johnjoe McFadden, University of Surrey

Transcriptome analysis reveals differential innate immune response of bovine macrophages to strains of the Mycobacterium tuberculosis complex
Kevin Rue-Albrecht, David A. Magee, Kevin M. Conlon, Nicolas C. Nalpas, John A. Browne, Paul A. McGettigan, Claire Healy, Kirsten E. McLoughlin, Eamonn Gormley, David E. MacHugh and Stephen V. Gordon, University College Dublin

Tetrahydrobiopterin production by macrophages is not required for protective immunity to Mycobacterium tuberculosis
Elena Stylianou, Eileen McNeill, Rachel Kandt, Keith Channon, Helen McShane, The Jenner Institute, University of Oxford

A brief history of the Acid Fast Club
Ann Rawkins, Public Health England, Porton Down

Session 3: Offered papers

Degradosome as one of the major RNA processing complexes in mycobacteria
Przemyslaw Plocinski, Maria Macios, Emilia Niemiec, Joanna Houghton, Douglas Young and Andrzej Dziembowski, Institute of Biochemistry and Biophysics Polish Academy of Sciences

NO biomarker for TB –  Expired nitric oxide and lipid body content of tubercle bacilli in sputum
Baye Gelaw, Natalie J. Garton, Gashaw Mesele,Tadye Abeje, Salie Ayalew, Pranabashis Haldar, Abraham Assefa, and Michael R Barer, Department of Medical Microbiology, CMHS, UOG, Ethiopia

Whole genome sequencing of Mycobacterium tuberculosis from sputum: a revolution in diagnostic microbiology
Amanda Claire Brown and members of the PathSeek project consortium, Oxford Gene Technology

Characterisation of host genetic factors that influence pathogen-host interplay during Mycobacterium tuberculosis infection
K. M. Kreutzfeldt, L. Mullen, C. Finan, S. J. Waddell, A. Marchant, M. J. Newportand S. M. Sacre, Brighton & Sussex Medical School, University of Sussex

The use of gene expression profiling in Mycobacterium tuberculosis as a tool to study drug efficacy and action
Dimitrios Evangelopoulos, Aidan Hanrath,Iva Treveska, Magdalena Karlikowska, Isobella Honeyborne, Sanjib Bhakta, Simon Waddel, Philip Butcherand Timothy D. McHugh, Centre for Clinical Microbiology, Royal Free Campus, University College London

Session 4: Offered papers

Development of a BCG challenge model for the testing of vaccine candidates against bovine tuberculosis
Villarreal-Ramos, B., Berg, S., Chamberlain, L., McShane, H., Hewinson, R. G., Clifford, D., Vordermeier, M., Bovine TB Group, AHVLA, Weybridge, New Haw, Surrey

Metabolite-Regulated Shutdown of Efflux Pumps is Critical for Mycobacterial Survival in Non-Permissive Growth Conditions
Obolbek Turapov, Simon J Waddell, Asel Sarybaeva, Bernard Burke, Sarah Glenn, Griselda Tudo, Gilles Labesse, Danielle I. Young, Michael YoungPeter W. Andrew, Philip D. Butcher, Martin Cohen-Gonsaud,Galina V. Mukamolova, Department of Infection, Immunity and Inflammation, University of Leicester

Redefining the mechanism of action of D-cycloserine in Mycobacterium tuberculosis
Gareth A. Prosser, Luiz Pedro Carvalho, National Institute for Medical Research, The Ridgeway, Mill Hill, London

AZALEP A randomized controlled trial of azathioprine to treat leprosy nerve damage and reactions in India: main findings
Lockwood DNJ, Darlong J, Pichimani G, Royce KK, Sundar Rao, Annamma John, London School of Hygiene & Tropical Medicine, London

A guide to killing your host cell, by Mycobacterium tuberculosis
Graham Stewart, Robert Francis, Rachel Butler, Tom Mendum, Shaza Felemban, University of Surrey

Meeting programme details Word file


AFC Summer 2005 meeting

AFC Summer 2005

Held at the University of Birmingham Medical school

July 15th 2005

Scientific Programme

Session 1

mycoDB: an online resource for mycobacterial genomics
Roy Chaudhuri, Birmingham University

Intranasal IFN-gamma extends the period of passive protection by IgA anti-acr mAB in Mycobacterium tuberculosis aerosol infected BALB/c mice
Rajko Reljic, Ann Williams, Simon Clark, Stephan Challacombe, Philip Marsh, & Juraj Ivanyi, Guys Hospital Campus, Kings College London

VNTR/MIRU typing of M. tuberculosis: a useful tool in TB control?
Krishna K Gopaul, Timothy J Brown, Andrea L Gibson, Malcolm D Yates & Francis A Drobniewski, HPA, Mycobacterium Reference Unit, London

A prospective study of paradoxical reactions in tuberculosis patients
RAM Breen, F Perrin, JP Dilworth, I Cropley, MA Johnson & MCI Lipman. Depts of Thoracic & HIV Medicine, Royal Free Hospital, London

The α-crystallin-like acr gene is responsible for hypervirulence in an Mycobacterium tuberculosis ΔdosR mutant
Yanmin Hu , Farahnaz Movahedzadeh , Neil G. Stoker & Anthony R. M. Coates. Dept Medical Microbiology, St George’s University of London and the Royal Veterinary College

Session 2

Development of a Detection System to Identify TB-specific CD8 T-cell Responses Induced by Vaccination with BCG and Boosted with a Recombinant Viral Vector
Kathryn T Whelan, Clare R Sander, Ansar A Pathan, Helen A Fletcher, Tamara K Berthoud, Adrian VS Hill & Helen McShane, University of Oxford

Rapid identification of Mycobacterium tuberculosis (MTC) and non-tuberculosis (NTB) in a routine diagnostic laboratory
Kerry J. Williams, Clare Ling, Claire Jenkins, Stephen H Gillespie & Timothy D. McHugh. Centre for Medical Microbiology, Hampstead Campus, UCL

How does anti-TNF-α treatment in patients with autoimmune disease lead to increased susceptibility to tuberculosis?
Newton S.M., Mackie S., Martineau A.R., Wilkinson K.A, Fischer C., Dhutta S., Kampmann B., Levin M., Wilkinson R.J. & Pasvol G. Wellcome Centre for Clinical Tropical Medicine, Imperial College

Detection of bovine tuberculosis in spill-over hosts
Jahans KL, Worth D, Brown J & Monies RJ. Veterinary Laboratories Agency, Addlestone, Surrey

AFC Winter 2005 meeting

AFC Winter 2005

January 2005

Scientific Programme

Session 1
What do microarrays really tell us about M. tuberculosis?
Neil Stoker

Evaluation of TB vaccines in guinea pigs – challenges and solutions to improve discrimination between candidates
Ann Williams, Hatch GJ, Clark SO, Gooch K, Hatch K, Hall GA, Marsh PD. (submitted by J. Ivanyi)

Ancient DNA analysis of cases of lepromatous leprosy from the archaeological record
C L Watson, S Mays D N J Lockwood & G M Taylor

Role of Mycobacterium tuberculosis PGL derivative, pHBAD-II, in innate immunity.
Ruth Griffin, Pearline Benjamin, Steven Coade, Germain Puzo, Brigitte Gicquel, Roger Buxton, Douglas Young, Mary Jackson, Ricardo Tascon Douglas Lowrie

Investigation of rifampicin resistance in isoniazid resistant strains of Mycobacterium tuberculosis isolated during an outbreak in North London
C. Jenkins, A. Claxton, R.J. Shorten, T.D. McHugh and S.H. Gillespie

Vitamin D: a double-edged sword in anti-mycobacterial immunity?
Martineau AR, Newton SM, Wilkinson KA, Norman AW, Griffiths CJ, Wilkinson RJ

Session 2
Effectiveness and acceptability of TB screening: a randomised trial and qualitative study
Chris Griffiths, Pat Sturdy, Penny Brewin, Meg McDonald, Adrian Martineau, Sandra Eldridge, Gene Feder, Miriam Beeks, Anna Jones, Graham Bothamley, Moira Kelly, Jean Ramsay, Ali Zumla

Disseminated Mycobacterium TB infection due to functional IFN-gamma deficiency
SL Seneviratne, R Doffinger , J McFarlane, L Ceron-Gutierrez, MR Amel Kasipaz, A Robbins, P Powell, DS Kumararatne, RJ Powell

A FHA domain-containing phospho-dependent signalling pathway of Mycobacterium tuberculosis is required for virulence in mice
Juliet M. Curry, Rachael Whalan, Debbie M. Hunt, Kalpesh Gohil, Molly Strom, Lisa Rickman, M. Joseph Colston, Stephen J. Smerdon and Roger S. Buxton

Regulating gene expression in mycobacteria. All in the ‘mind’
Marian C. J. Blokpoel, Helen Murphy, Ronan O’Toole, Siouxsie Wiles, Graham R. Stewart, Douglas B. Young, Brian D. Robertson

Control of M. bovis in the presence of a wildlife reservoir
Dirk Pfeiffer (submitted by Neil Stoker)

AFC Summer 2004 meeting

AFC Summer 2004

July 2004

Scientific Programme

Session 1

Methionine- the preferred sulphur source for pathogenic mycobacteria? Refining the genomic information with metabolic investigations
Paul R Wheeler, Nicholas G Coldham, Lisa Keating, Stephen V Gordon, Esen E Wooff, Tanya Parish and R Glyn Hewinson. VLA

Effect of prednisolone treatment on cytokine expression in leprosy patients with type 1 reaction (T1R)
Anna K Andersson, Mehervani Chaduvula, Sara Atkinson, Saroj Khanolkar-Young, Martin Holland, Suman Jain, Lavanya Suneetha, Sujai Suneetha and Diana N J Lockwood. London School of Hygiene and Tropical Medicine

Characteristic genomic deletion pattern in clinical isolates of M. tuberculosis from South Asian patients
M. Carmen Menendez, Rahizan Issa, Roger S. Buxton, Evangelos Stavropoulos, Peter M. Hawkey and M. Joseph Colston

The role of oxidative stress in Mycobacterium tuberculosis evolution
O’ Sullivan D, McHugh TD, Gillespie SH. Royal Free & University College London Medical School

IFN gamma responses in young adults from the UK BCG programme: The first SSI BCG vaccinated cohort
Patricia Gorak-Stolinska, Rosemary E. Weir, Maeve Lalor, Rose Blitz, Nisha Faruk, Paul E.M. Fine, Hazel M. Dockrell. London School of Hygiene and Tropical Medicine

DGAT, FATP and FACS, does the TAG team do it for M tuberculosis in vivo?
Natalie Garton, University of Leicester

Session 2

An investigation of the phenotype of an outbreak strain of M. tuberculosis.
SM Newton, KA Wilkinson, RJ Smith, GR Stewart, JR Wain, RA Stabler, P Butcher, J Shafi, P Andrew, M Barer, RJ Wilkinson Imperial College London

Involvement of a specific phospholipase D isoform in the ATP-mediated killing of intracellular mycobacteria
Lorna Forse, Cheuk Li and Tony Lammas. University of Birmingham

IL-4 delta 2 and Th2 cytokines in human Pulmonary Tuberculosis
K Dheda, JF Huggett, MA Johnson, A Zumla and G Rook. UCL and Royal Free Medical School

Population genetics of Mycobacterium bovis field strains from cattle in Iran
Tadayon, Keyvan, Forbes, Ken. University of Aberdeen

Did mutational ablation of a CRP-like global regulator contribute to the attenuation of BCG? Claire Spreadbury and Mark Pallen